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KMID : 0378019740170111539
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New Medical Journal
1974 Volume.17 No. 11 p.1539 ~ p.1544
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Ultrastructural Changes of Lymphocytes in Lymph Nodes of Rats following Injury
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Abstract
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An attempt was made to observe the ultra structural changes of lymphocytes in the lymph node of rats inflicted the injury. Albino rats were used, and their mesenteric lymph nodes were examined by light- or electron-microscopy. Experimental groups were consisted of control, burned (1 or 4 days after burn) and formalin injected (1 or 7 times of injection) ones.
The results were as follows:
The first evidence of damage detected were the appearance in the cytoplasm of local aggregations of ribosome-like particles and lamellated figure attached to the portion of disrupted nuclear membrane, and the coarse aggregation of nuclear chromatin. And more advanced changes showed ragged cavities in nucleus, disruption of nuclear membrane, and swelling of mitochondria, disruption of mitochondial cristae, loss of ribosomes and disruption of plasma membrane. Finally the appearance of dense amorphous materials in the nuclear portion and the loss of all the cytoplasmic organelles was shown.
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KEYWORD
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